500 [پانصد] خودنگاره

500 Solutions

No problem is ever permanently closed. The editor is always pleased to consider for publication new solutions or new insights o n p a s t p r oblems. (1) Determine the set of all c > 0 such that whenever (1) holds, then we have x + y + z xy + yz+ zx. The positive r eals c asked for are those satisfying c 4. From (1), we have xy < c and z = c ; xy x + y + xy. Substituting this value of z into th...

Mol081083 490..500

Membrane transporter proteins may influence the sensitivity of cancer cells to anticancer drugs that can be recognized as substrates. The purpose of this study was to identify proteins that play a key role in the drug sensitivity of stomach and breast cancer cell lines by measuring the absolute protein expression levels of multiple transporters and other membrane proteins and examining their co...

C4nr03962a 500..510 ++

Tumor associated macrophages (TAMs) can modify the tumor microenvironment to create a pro-tumor niche. Manipulation of the TAM phenotype is a novel, potential therapeutic approach to engage anticancer immunity. siRNA is a molecular tool for knockdown of specific mRNAs that is tunable in both strength and duration. The use of siRNA to reprogram TAMs to adopt an immunogenic, anti-tumor phenotype ...

Edition of 500 Copies

Op-heap140025 500..507

Département de Santé Publique, Unité de Recherche sur les Politiques et Systèmes de Santé, Centre Muraz, 2054 Avenue Mamadou Konaté, 01 BP 390 Bobo-Dioulasso, Burkina Faso Agence de Formation, de Recherche et d’Expertise en Santé pour l’Afrique (AFRICSanté), 773 Rue Guillaume Ouédraogo 01 BP 298 Bobo-Dioulasso, Burkina Faso Department of Community Medicine, University of Oslo, Post Box 1130 Bli...

Introducing the Graph 500

In the words of Lord Kelvin, “if you cannot measure it, you cannot improve it”. One of the longlasting successes of the Top 500 list is sustained, community-wide floating point performance improvement. Emerging large-data problems, either resulting from measured real-world phenomena or as further processing of data generated by simulation, have radically different performance characteristics an...